"Braking" the Cycle of Resistance in Endocrine Therapy for Breast Cancer.

نویسندگان

  • Angela DeMichele
  • Lewis A Chodosh
چکیده

Endocrine resistance leads to recurrence and death from breast cancer. Animal models of endocrine resistance enable preclinical identification of efficacious therapeutic combinations and further our understanding of resistance. This strategy provides new insights into optimally targeting interactions between estrogen receptor (ESR-1) activity and the cell cycle by CDK4/6 inhibitors. See related article by Wardell et al., p. 5121.

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عنوان ژورنال:
  • Clinical cancer research : an official journal of the American Association for Cancer Research

دوره 21 22  شماره 

صفحات  -

تاریخ انتشار 2015